Tumor biomarkers are developed to indicate tumor status, clinical outcome, or prognosis. Since currently there are no effective\nbiomarkers for caninemammary tumor (CMT), this study intended to verify whether kynurenine 3-monooxygenase (KMO), one\nof the key enzymes involved in tryptophan catabolism, is competent for predicting prognosis in patients with CMT. By investigating\na series of 86 CMT clinical cases, we found that both gene and protein expression of KMO discriminated malignant from benign\nCMTs and was significantly higher in stage IV and V tumors than in lower-stage CMTs. About 73.7% of malignant CMTs showed\nstrong expression of KMO which correlated with lower overall survival rates in patients. Further, downregulation of KMO activity\nsignificantly inhibited cell proliferation of CMT cells. Taken together, the findings indicated that KMO is a potential biomarker for\ntumor diagnosis, and this might open up new perspectives for clinical applications of CMT.
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